INNOVA4TB

Improving TB management

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WP3: Development of new diagnostic methods

Remote analysis of sputum smears for mycobacterium tuberculosis quantification using digital crowdsourcing. Lara García Delgado, María Postigo, Daniel Cuadrado, Sara Gil-Casanova, Álvaro Martínez Martínez, María Linares, Paloma Merino, Manuel Gimo, Silvia Blanco, Quique Bassat, Andrés Santos, Alberto L. García- Basteiro, María J. Ledesma-Carbayo, Miguel A Luengo-Oroz. PLoS ONE 17(5): e0268494. https://doi.org/10.1371/journal.pone.0268494.

WP3: Development of new diagnostic methods

Study of CD27, CD38, HLA-DR and Ki-67 immune profiles for the characterization of active tuberculosis, latent infection and end of treatment. Sergio Díaz-Fernández, Raquel Villar-Hernández, Zoran Stojanovic, Marco Fernández, Maria Luiza De Souza Galvão, Guillermo Tolosa, Adrián Sánchez-Montalva, Jorge Abad, María Ángeles Jiménez-Fuentes, Guillem Safont, Iris Romero, Josefina Sabrià, Cristina Prat, Jose Domínguez & Irene Latorre. Front. Microbiol. 13:885312. doi: 10.3389/fmicb.2022.885312

WP3: Development of new diagnostic methods

Urine NMR‑based TB metabolic fingerprinting for the diagnosis of TB in children. Patricia Comella‑del‑Barrio, José Luis Izquierdo‑Garcia, Jacqueline Gautier, Mariette Jean Coute Doresca, Ramón Campos‑Olivas, Clara M. Santiveri, Beatriz Muriel‑Moreno, Cristina Prat‑Aymerich, Rosa Abellana, Tomas M. Pérez‑Porcuna, Luis E. Cuevas, Jesús Ruiz‑Cabello & José Domínguez. Sci Rep 2021 Jun 7;11(1):12006; https://doi.org/10.1038/s41598-021-91545-0

WP3: Development of new diagnostic methods

Diagnostic Performance of the Fujifilm SILVAMP TB-LAM in Children with Presumptive Tuberculosis. Patricia Comella-del-Barrio, Bárbara Molina-Moya, Jacqueline Gautier, Raquel Villar-Hernández, Mariette Jean Coute Doresca, Beatriz Sallés-Mingels, Lydia Canales-Aliaga, Margareth Narcisse, Tomás M. Pérez-Porcuna, Jacob Creswell, Luis E. Cuevas and José Domínguez. J. Clin. Med. 2021, 10(9), 1914; https://doi.org/10.3390/jcm10091914

Impact of COVID-19 on tuberculosis control. Patricia Comella-del-Barrio, Maria Luiza De Souza-Galvão, Cristina Prat-Aymerich, José Domínguez. Editorial/Arch Bronconeumol. 2021;57(S2):5–6; https://doi.org/10.1016/j.arbres.2020.11.016.

WP3: Development of new diagnostic methods

Molecular Detection of Mycobacterium tuberculosis in Oral Mucosa from Patients with Presumptive Tuberculosis. Barbara Molina-Moya, Nelly Ciobanu, Marta Hernandez, Cristina Prat-Aymerich, Valeriu Crudu, Emily R. Adams, Alexandru Codreanu, Derek J. Sloan, Luis E. Cuevas and Jose Dominguez. J. Clin. Med. 2020, 9, 4124; doi:10.3390/jcm9124124

WP3: Development of new diagnostic methods

Discovery and validation of an NMR-based metabolomic profile in urine as TB biomarker. José Luis Izquierdo‐Garcia, Patricia Comella‐del‐Barrio, Ramón Campos‐Olivas, Raquel Villar‐Hernández, Cristina Prat‐Aymerich, Maria Luiza De Souza‐Galvão, Maria Angeles Jiménez‐Fuentes, Juan Ruiz‐Manzano, Zoran Stojanovic, Adela González, Mar Serra‐Vidal, Esther García‐García, Beatriz Muriel‐Moreno, Joan Pau Millet, Israel Molina‐Pinargote, Xavier Casas, Javier Santiago, Fina Sabriá, Carmen Martos, Christian Herzmann, Jesús Ruiz‐Cabello and José Domínguez. Sci Rep 10, 22317 (2020); https://doi.org/10.1038/s41598-020-78999-4

WP3: Development of new diagnostic methods

Cell-Mediated Immune Responses to in vivo-Expressed and Stage-Specific Mycobacterium tuberculosis Antigens in Latent and Active Tuberculosis Across Different Age Groups. Coppola M, Villar-Hernández R, van Meijgaarden KE, Latorre I, Muriel Moreno B, Garcia-Garcia E, Franken KLMC, Prat C, Stojanovic Z, De Souza Galvão ML, Millet J-P, Sabriá J, Sánchez-Montalva A, Noguera-Julian A, Geluk A, Domínguez J and Ottenhoff THM. Front. Immunol. (2020) 11:103. doi: 10.3389/fimmu.2020.00103

WP3: Development of new diagnostic methods

Study of CD27 and CCR4 Markers on Specific CD4+ T-Cells as Immune Tools for Active and Latent Tuberculosis Management. Latorre I, Fernández-Sanmartín MA, Muriel-Moreno B, Villar-Hernández R, Vila S, Souza-Galvão MLD, Stojanovic Z, Jiménez-Fuentes MÁ, Centeno C, Ruiz-Manzano J, Millet J-P, Molina-Pinargote I, González-Díaz YD, Lacoma A, Luque-Chacón L, Sabriá J, Prat C and Domínguez J. Front. Immunol. (2019), 9:3094; doi: 10.3389/fimmu.2018.03094

WP5: Development of new therapeutic strategies

Matryoshka-type gastro-resistant microparticles for the oral treatment of Mycobacterium tuberculosis. Vanesa Andreu, Ane Larrea, Pablo Rodriguez-Fernandez, Salvador Alfaro, Begoña Gracia, Ainhoa Lucía, Laura Usón, Andromeda-Celeste Gomez, Gracia Mendoza, Alicia Lacoma, Jose Dominguez, Cristina Prat, Victor Sebastian, José Antonio Ainsa & Manuel Arruebo. Nanomedicine (Lond). 2019 Mar;14(6):707-726. DOI: 10.2217/nnm-2018-0258

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