OBJECTIVES
What we want to do
WORK PACKAGES
What we are going to do
Identify the population with a high risk of developing TB.
Find specific biomarkers of latency and the risk of progression.
Search for a blood signature of progression to active TB using a transcriptomics.
Study primary immunodeficiencies by whole-exome sequencing.
WP3: DEVELOPMENT OF NEW DIAGNOSTIC METHODS
Develop, evaluate and determine the efficacy of new rapid methods, cost-affordable, for diagnosing active TB and also monitoring treatment.
Diagnostic imaging.
Automatic system to read smears.
Immunomagnetic microfluidic concentrator and separator of target elements.
Metabolomics.
WP4: DEVELOPMENT OF TESTS FOR MULTI/EXTENSIVELY DRUG-RESISTANT TB DETECTION
Focus on technologies able to detect multiple targets.
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Circularized padlock probe amplification and read-out by lateral flow assay.
High-throughput detection on a 96-well array.
WP1: MANAGEMENT AND TRAINING
Train the staff participating in the project, to improve their professional careers and improve the scientific results of the project.
WP2: STUDY OF THE HOST-PATHOGEN INTERACTION
WP5: DEVELOPMENT OF NEW THERAPEUTIC STRATEGIES
Anti-TB drug delivery using nanoparticles and assessment of new biomarkers-kinetics of cell markers and inflammatory proteins.
WP6: DISSEMINATION, COMMUNICATION AND EXPLOITATION
Social media
Conferences and meetings
Open access research publications