OBJECTIVES
What we want to do
TO IMPROVE THE UNDERSTANDING OF HOST-PATHOGEN INTERACTION DURING LATENCY
WORK PACKAGES
What we are going to do
WP1: MANAGEMENT AND TRAINING
Identify the population with a high risk of developing TB.
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Find specific biomarkers of latency and the risk of progression.
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Search for a blood signature of progression to active TB using a transcriptomics.
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Study primary immunodeficiencies by whole-exome sequencing.
Develop, evaluate and determine the efficacy of new rapid methods, cost-affordable, for diagnosing active TB and also monitoring treatment.
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Diagnostic imaging.
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Automatic system to read smears.
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Immunomagnetic microfluidic concentrator and separator of target elements.
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Metabolomics.
Focus on technologies able to detect multiple targets.
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Circularized padlock probe amplification and read-out by lateral flow assay.
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High-throughput detection on a 96-well array.
WP3: DEVELOPMENT OF NEW DIAGNOSTIC METHODS
WP4: DEVELOPMENT OF TESTS FOR MULTI/EXTENSIVELY DRUG-RESISTANT TB DETECTION
Anti-TB drug delivery using nanoparticles and assessment of new biomarkers-kinetics of cell markers and inflammatory proteins.
WP5: DEVELOPMENT OF NEW THERAPEUTIC STRATEGIES
WP6: DISSEMINATION, COMMUNICATION AND EXPLOITATION
Social media
Conferences and meetings
Open access research publications
Train the staff participating in the project, to improve their professional careers and improve the scientific results of the project.