OBJECTIVES

What we want to do

TO IMPROVE THE UNDERSTANDING OF HOST-PATHOGEN INTERACTION DURING LATENCY

WORK PACKAGES

What we are going to do

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WP1: MANAGEMENT AND TRAINING

 

​Identify the population with a high risk of developing TB. 

  • ​Find specific biomarkers of latency and the risk of progression.

  • Search for a blood signature of progression to active TB using a transcriptomics.

  • Study primary immunodeficiencies by whole-exome sequencing. 

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Develop, evaluate and determine the efficacy of new rapid methods, cost-affordable, for diagnosing active TB and also monitoring treatment. 

 

  • Diagnostic imaging.

  • Automatic system to read smears.

  • Immunomagnetic microfluidic concentrator and separator of target elements.

  • Metabolomics.

 

Focus on technologies able to detect multiple targets.

  • Circularized padlock probe amplification and read-out by lateral flow assay.

  • High-throughput detection on a 96-well array.

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WP3: DEVELOPMENT OF NEW DIAGNOSTIC METHODS

WP4: DEVELOPMENT OF TESTS FOR MULTI/EXTENSIVELY DRUG-RESISTANT TB DETECTION

Anti-TB drug delivery using nanoparticles and assessment of new biomarkers-kinetics of cell markers and inflammatory proteins.

WP5: DEVELOPMENT OF NEW THERAPEUTIC STRATEGIES

WP6: DISSEMINATION, COMMUNICATION AND EXPLOITATION

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Social media

Conferences and meetings

Open access research publications

 

 

Train the staff participating in the project, to improve their professional careers and improve the scientific results of the project.

WP2: STUDY OF THE HOST-PATHOGEN INTERACTION